Effectiveness of the primary Bacillus Calmette-Guérin vaccine against the risk of Mycobacterium tuberculosis infection and tuberculosis disease: a meta-analysis of individual participant data

This paper of the day talks about the Effectiveness of the primary Bacillus Calmette-Guérin vaccine against the risk of Mycobacterium tuberculosis infection and tuberculosis disease: a meta-analysis of individual participant data. The BCG vaccine was tested using a meta-analysis of individual subject data to determine whether it prevents getting Mycobacterium tuberculosis. The researchers included information from 14 studies, such as cohort studies and family contact studies. They found that the BCG vaccine often protected against tuberculosis sickness but was not always effective at preventing M. tuberculosis infections, as demonstrated by the QuantiFERON-TB Gold In-Tube (QFT-GIT) conversion. This varied by group. However, among people who shared a household, protection against QFT-GIT conversion was observed, and this was equivalent to that against disease. These results suggest that QFT-GIT conversion may be useful as an outcome measure for future TB vaccine studies.