Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering

     The paper of the day from bioactive materials talks about crosslinked hydrogels for bone tissue engineering. As bone tissue engineering emerged significantly providing novel tools in preparing biomimetic hydrogels which can be used in bone-related diseases like cartilage damage, bone defects, osteoarthritis, skull defects, etc. In this paper the crosslinked hydrogels are fabricated by physical crosslinking, chemical crosslinking and photo crosslinking. And it also gives many key points for hydrogel design in clinical applications like - polymers derived from macromolecules within organisms (nucleic acid, macromolecular proteins and glycosaminoglycans) and non-natural polymers (PVA, PEG and PCL) for treating various bone-related diseases. In the outlook and future it talks about focus on balance between complexity and simplicity in bone-related hydrogel design, simple fabrication process for advanced hydrogel designs and also about blindspot of hydrogel designs.